Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | HPGD | P15428 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ATM | Q13315 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048780 | 0.92 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4ETDP1L3MBTL1 | |
| SCHEMBL5425312 | 0.89 | ALDH1A1 (0.45) | ALDH1A1HPGDKDM4ETDP1L3MBTL1 | |
| SCHEMBL4046992 | 0.87 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4ETDP1L3MBTL1 | |
| SCHEMBL5422453 | 0.85 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4ETDP1L3MBTL1 | |
| SCHEMBL4040894 | 0.85 | MAPK1 (0.40) | ALDH1A1HPGDKDM4ETDP1L3MBTL1 | |
| SCHEMBL4043815 | 0.85 | PPARG (0.49) | ALDH1A1HPGDKDM4ETDP1L3MBTL1 | |
| SCHEMBL4053059 | 0.82 | NOTUM (0.50) | ALDH1A1HPGDKDM4ETDP1L3MBTL1 | |
| SCHEMBL5424297 | 0.82 | KDM4E (0.55) | ALDH1A1HPGDKDM4ETDP1L3MBTL1 | |
| SCHEMBL4045972 | 0.81 | ALDH1A1 (0.48) | ALDH1A1HPGDKDM4ETDP1L3MBTL1 | |
| SCHEMBL4048452 | 0.81 | MEN1 (0.43) | ALDH1A1HPGDKDM4ETDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603921-B1 | THIADIBENZOAZULENE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXOSMITHKLINE ZAGREB (HR) | 2009-06-17 | — | — | EP | disclosed |
| US-20060069149-A1 | Thiadibenzoazulene derivatives for the treatment of inflammatory diseases | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2006-03-30 | — | — | US | disclosed |
| EP-1603921-A1 | THIADIBENZOAZULENE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES | PLIVA-ISTRAZIVACKI INSTITUT d.o.o. (HR) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004078763-A1 | THIADIBENZOAZULENE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069149-A1 | Thiadibenzoazulene derivatives for the treatment of inflammatory diseases | IL1B, IL1A, TNF | ALDH1A1 35/4885HPGD 120/4885KDM4E 3071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.