Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 12/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 10/20 | 0.34 |
| ▸ | CTSS | P25774 | 6/20 | 0.34 |
| ▸ | CTSB | P07858 | 3/20 | 0.34 |
| ▸ | CTSV | O60911 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048179 | 0.93 | TSHR (0.36) | LMNATSHRSMN1; SMN2MCHR1ELANE | |
| SCHEMBL4045230 | 0.90 | CTSK (0.43) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4051956 | 0.90 | CTSK (0.41) | CTSKKMT2ACTSLCTSSCTSB | |
| SCHEMBL4045311 | 0.88 | CTSK (0.43) | CTSKSMN1; SMN2KMT2ACTSLCTSS | |
| SCHEMBL4050724 | 0.88 | CTSK (0.39) | CTSKLMNATSHRSMN1; SMN2CTSL | |
| SCHEMBL4050939 | 0.88 | CTSK (0.37) | CTSKTSHRKMT2ACTSLCTSS | |
| SCHEMBL4041598 | 0.87 | CTSK (0.40) | CTSKKMT2ACTSLCTSSCTSB | |
| SCHEMBL4045340 | 0.86 | CTSK (0.40) | CTSKSMN1; SMN2KMT2ACTSLCTSS | |
| SCHEMBL4043147 | 0.85 | CTSK (0.40) | CTSKSMN1; SMN2KMT2ACTSLCTSS | |
| SCHEMBL4043401 | 0.84 | CTSK (0.47) | CTSKLMNATSHRSMN1; SMN2CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |