Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 12/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 8/20 | 0.36 |
| ▸ | CTSS | P25774 | 6/20 | 0.36 |
| ▸ | CTSB | P07858 | 3/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043139 | 0.92 | ELANE (0.37) | CTSKKMT2AELANESMN1; SMN2ALDH1A1 | |
| SCHEMBL4051956 | 0.91 | CTSK (0.41) | CTSKKMT2AELANECTSLCTSS | |
| SCHEMBL4051785 | 0.90 | ITGA4 (0.39) | CTSKELANEALDH1A1MMP1MMP2 | |
| SCHEMBL4043147 | 0.89 | CTSK (0.40) | CTSKKMT2AELANECTSLCTSS | |
| SCHEMBL4045340 | 0.89 | CTSK (0.40) | CTSKKMT2AELANECTSLCTSS | |
| SCHEMBL4041598 | 0.89 | CTSK (0.40) | CTSKKMT2AELANECTSLCTSS | |
| SCHEMBL4042621 | 0.89 | CTSK (0.45) | CTSKCTSLCTSSCTSB | |
| SCHEMBL4045898 | 0.89 | CTSK (0.41) | CTSKKMT2AELANECTSLCTSS | |
| SCHEMBL4044539 | 0.89 | ITGA4 (0.36) | CTSKELANECTSLCTSSCTSB | |
| SCHEMBL4045599 | 0.88 | CTSK (0.39) | CTSKKMT2AELANECTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |