SCHEMBL4046027

SCHEMBL4046027

O=C(F)CN(C(=O)O)C1CCCC1

nearest known ligand 0.43

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGER Q15109 3/20 0.39
MTNR1A P48039 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9104933 0.80 AGER (0.38) AGERMTNR1A
SCHEMBL16653682 0.78 AGER (0.41) AGERMTNR1A
SCHEMBL4442911 0.78 AGER (0.41) AGERMTNR1A
SCHEMBL28521049 0.78 DPP4 (0.36)
SCHEMBL11288200 0.76 AGER (0.41) AGERMTNR1A
Fluoride SCHEMBL11411309 0.75 AGER (0.42) AGERMTNR1A
SCHEMBL1416895 0.75 SLC6A9 (0.40) AGERMTNR1A
SCHEMBL1416582 0.75 SLC6A9 (0.40) AGERMTNR1A
SCHEMBL22341270 0.74 AGER (0.41) AGERMTNR1A
SCHEMBL970095 0.74 L3MBTL1 (0.51)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2046798-A1 FURO [3,2-B]PYRROL-3-ONE DERIVATIVES AND THEIR USE AS CYSTEINYL PROTEINASE INHIBITORS Amura Therapeutics Limited (GB) 2009-04-15 EP disclosed
WO-2008007130-A1 FURO [3,2-B] PYRROL-3-ONE DERIVATIVES AND THEIR USE AS CYSTEINYL PROTEINASE INHIBITORS AMURA THERAPEUTICS LIMITED (GB) 2008-01-17 WO disclosed