Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 12/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27718208 | 0.80 | NNMT (0.36) | SYK | |
| SCHEMBL3964609 | 0.71 | AURKA (0.42) | AURKAAURKBIGF1RFGFR1KDR | |
| SCHEMBL29784057 | 0.71 | CCNA2 (0.42) | AURKAAURKBSYKCCNA2CDK2 | |
| SCHEMBL3951464 | 0.70 | IGF1R (0.49) | AURKAAURKBIGF1RFGFR1KDR | |
| SCHEMBL27718225 | 0.70 | KMT2A (0.39) | AURKAAURKB | |
| SCHEMBL27913740 | 0.70 | ADORA3 (0.45) | — | |
| SCHEMBL29972030 | 0.69 | CCNA2 (0.58) | CCNA2CDK2CCNA1 | |
| SCHEMBL29650246 | 0.69 | RET (0.54) | AURKAAURKBIGF1RKDR | |
| SCHEMBL4046163 | 0.67 | AURKA (0.41) | AURKAAURKBIGF1RFGFR1KDR | |
| SCHEMBL14657619 | 0.66 | IGF1R (0.64) | AURKAAURKBIGF1RSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111212833-B | Phenylpyridine derivatives and pharmaceutical compositions containing the same | 株式会社大熊制药 | 2022-09-06 | — | — | CN | claimed |
| CN-111212833-A | Novel phenylpyridine derivative and pharmaceutical composition comprising same | 株式会社大熊制药 | 2020-05-29 | — | — | CN | claimed |
| CN-111212833-B | Phenylpyridine derivatives and pharmaceutical compositions containing the same | 株式会社大熊制药 | 2022-09-06 | — | — | CN | disclosed |
| CN-111212833-A | Novel phenylpyridine derivative and pharmaceutical composition comprising same | 株式会社大熊制药 | 2020-05-29 | — | — | CN | disclosed |