Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 6/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.45 |
| ▸ | AURKA | O14965 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 4/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | RXRG | P48443 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 6/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4044514 | 0.84 | FLT3 (0.46) | FLT3IRAK4AURKAEGFRKIT | |
| SCHEMBL12780498 | 0.84 | FLT3 (0.46) | FLT3IRAK4AURKAEGFRKIT | |
| SCHEMBL4038443 | 0.81 | FLT3 (0.44) | FLT3IRAK4AURKAEGFRKIT | |
| SCHEMBL4046831 | 0.81 | FLT3 (0.63) | FLT3IRAK4AURKAKITPTK2 | |
| SCHEMBL4044855 | 0.80 | AURKA (0.50) | FLT3IRAK4AURKAKITAXL | |
| SCHEMBL4039049 | 0.79 | FLT3 (0.63) | FLT3IRAK4AURKAKITPTK2 | |
| SCHEMBL4040322 | 0.76 | FLT3 (0.67) | FLT3IRAK4AURKAEGFRKIT | |
| SCHEMBL2086579 | 0.76 | FLT3 (0.48) | FLT3IRAK4AURKAKITAXL | |
| SCHEMBL4039634 | 0.74 | FLT3 (0.45) | FLT3IRAK4AURKAKITAXL | |
| SCHEMBL4040753 | 0.73 | FLT3 (0.43) | FLT3IRAK4AURKAKITPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |