Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 7/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 5/20 | 0.39 |
| ▸ | BACE1 | P56817 | 4/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4044453 | 0.82 | FLT3 (0.59) | FLT3IRAK4AURKAKITADORA2A | |
| SCHEMBL4039634 | 0.74 | FLT3 (0.45) | FLT3IRAK4AURKAKITJAK2 | |
| SCHEMBL4040322 | 0.74 | FLT3 (0.67) | FLT3IRAK4AURKAKITJAK2 | |
| SCHEMBL4046935 | 0.73 | FLT3 (0.45) | FLT3IRAK4AURKAKITBACE1 | |
| SCHEMBL2086579 | 0.73 | FLT3 (0.48) | FLT3IRAK4AURKAKITBACE1 | |
| SCHEMBL6224723 | 0.69 | ULK1 (0.44) | FLT3IRAK4AURKAKITBACE1 | |
| SCHEMBL4043796 | 0.68 | FLT3 (0.61) | FLT3IRAK4AURKAKITJAK2 | |
| SCHEMBL13963975 | 0.68 | AXL (0.44) | FLT3IRAK4AURKAKITBACE1 | |
| SCHEMBL12782391 | 0.67 | FLT3 (0.44) | FLT3IRAK4AURKAKITBACE1 | |
| SCHEMBL20260472 | 0.67 | BACE1 (0.38) | BACE1ADORA2AJAK2SRCCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |