Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.36 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.35 |
| ▸ | STAT6 | P42226 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | PLD2 | O14939 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CCKBR | P32239 | 1/20 | 0.33 |
| ▸ | PYGL | P06737 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050835 | 0.90 | DRD2 (0.39) | DRD2PLD1CYP51A1STAT6CNR2 | |
| SCHEMBL4059459 | 0.86 | PYGL (0.38) | DRD2PLD1CYP51A1STAT6PYGL | |
| SCHEMBL4051527 | 0.86 | DRD3 (0.39) | DRD2PLD1CYP51A1STAT6PYGL | |
| SCHEMBL4058360 | 0.84 | DRD2 (0.36) | DRD2PLD1CYP51A1STAT6ALDH1A1 | |
| SCHEMBL4051134 | 0.83 | DRD2 (0.38) | DRD2PLD1CYP51A1STAT6CNR2 | |
| SCHEMBL19856897 | 0.82 | DRD2 (0.41) | DRD2CYP51A1STAT6KDM4ECNR2 | |
| SCHEMBL19856899 | 0.82 | DRD2 (0.41) | DRD2CYP51A1STAT6KDM4ECNR2 | |
| SCHEMBL8004902 | 0.81 | DRD2 (0.38) | DRD2CYP51A1STAT6CCKBRPYGL | |
| SCHEMBL1549547 | 0.80 | PDGFRB (0.46) | DRD2CYP51A1STAT6PYGLAKR1C3 | |
| SCHEMBL1549906 | 0.80 | DRD2 (0.42) | DRD2CYP51A1STAT6KDM4ECNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | claimed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |