Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.44 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049899 | 1.00 | SPHK2 (0.44) | SPHK2SPHK1ROCK2GABRA5CNR2 | |
| SCHEMBL13690754 | 0.88 | GPR119 (0.55) | SPHK2SPHK1ROCK2GPR119 | |
| SCHEMBL13690495 | 0.88 | GPR119 (0.55) | SPHK2SPHK1ROCK2GPR119 | |
| SCHEMBL4460046 | 0.84 | SPHK2 (0.46) | SPHK2SPHK1ROCK2CNR2POLB | |
| SCHEMBL16803765 | 0.84 | ROCK2 (0.40) | SPHK2SPHK1ROCK2GABRA5CNR2 | |
| SCHEMBL4370900 | 0.83 | IKBKB (0.48) | SPHK2SPHK1ROCK2ATRHRH3 | |
| SCHEMBL4057216 | 0.83 | IKBKB (0.48) | SPHK2SPHK1ROCK2ATRHRH3 | |
| SCHEMBL4388608 | 0.82 | ATR (0.42) | GABRA5ATRGPR119HRH3 | |
| SCHEMBL15538334 | 0.82 | SPHK2 (0.41) | SPHK2SPHK1ROCK2GABRA5CNR2 | |
| SCHEMBL16777185 | 0.82 | SPHK2 (0.41) | SPHK2SPHK1ROCK2GABRA5CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |