Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972992 | 0.92 | HTR6 (0.50) | HTR6TP53MAPTLMNAALDH1A1 | |
| SCHEMBL3898623 | 0.86 | HTR6 (0.56) | HTR6TP53MAPTLMNAALDH1A1 | |
| SCHEMBL4050508 | 0.84 | HTR6 (0.40) | HTR6TP53MAPTLMNAALDH1A1 | |
| SCHEMBL314648 | 0.73 | HTR2C (0.46) | HTR6MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9324361 | 0.69 | HTR6 (0.58) | HTR6MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL3902873 | 0.68 | HTR6 (0.49) | HTR6TP53MAPTLMNAALDH1A1 | |
| SCHEMBL9715425 | 0.68 | BAZ2B (0.60) | LMNAALDH1A1SMN1; SMN2L3MBTL1THRB | |
| SCHEMBL9523269 | 0.66 | NPC1 (0.55) | MAPTALDH1A1SMN1; SMN2L3MBTL1BAZ2B | |
| SCHEMBL316166 | 0.66 | GRM5 (0.54) | HTR6LMNAALDH1A1THRBGRM5 | |
| SCHEMBL28383011 | 0.64 | DRD2 (0.58) | HTR6LMNAALDH1A1SMN1; SMN2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076489-A1 | ARYLSULFONAMIDYL TETRALIN DERIVATIVES AND USES THEREOF | F. Hoffmann-Roche AG (CH) | 2009-07-08 | — | — | EP | disclosed |
| WO-2007147762-A1 | ARYLSULFONAMIDYL TETRALIN DERIVATIVES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-27 | — | — | WO | disclosed |