Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.60 |
| ▸ | MAOA | P21397 | 3/20 | 0.50 |
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | PRKCI | P41743 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | TDP2 | O95551 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1091899 | 0.90 | PTGS2 (0.48) | BAZ2BGAAHPGDMAPK1TDP2 | |
| SCHEMBL9591484 | 0.89 | MET (0.47) | BAZ2BMAOAMAOBLMNAALDH1A1 | |
| SCHEMBL1091569 | 0.85 | TDP2 (0.61) | BAZ2BHSD17B1BRD4TDP2 | |
| SCHEMBL18422825 | 0.83 | LMNA (0.64) | LMNAALDH1A1SMN1; SMN2THRBL3MBTL1 | |
| SCHEMBL30023674 | 0.83 | LMNA (0.64) | LMNAALDH1A1SMN1; SMN2THRBL3MBTL1 | |
| SCHEMBL8310779 | 0.80 | BAZ2B (0.67) | BAZ2BMAOAMAOBPRKCIMAPK1 | |
| SCHEMBL15220226 | 0.80 | LMNA (0.59) | LMNAALDH1A1SMN1; SMN2GAAHPGD | |
| SCHEMBL3898623 | 0.80 | HTR6 (0.56) | BAZ2BMAOAMAOBLMNAALDH1A1 | |
| SCHEMBL30612414 | 0.75 | BAZ2B (1.00) | BAZ2BMAOAMAOBPRKCIALDH1A1 | |
| SCHEMBL315269 | 0.75 | BAZ2B (1.00) | BAZ2BMAOAMAOBPRKCIALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140040-A | Alpha-2-adrenergic receptor antagonist; glaucoma; congestive heart failure; hypotensive agents; headaches; metabolic disorders (diabetes, obesity) | ABBOTT LABORATORIES (US) | 1992-08-18 | — | — | US | disclosed |
| US-5128362-A | Antidepressant, antiglaucoma | ABBOTT LABORATORIES (US) | 1992-07-07 | — | — | US | disclosed |
| US-5086074-A | Selective adrenergic receptor antagonists | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |