Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.41 |
| ▸ | P2RY4 | P51582 | 2/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1748994 | 0.76 | HSD17B10 (0.48) | HSD17B10MAPK8CAMKK2ABCG2JAK2 | |
| SCHEMBL27978206 | 0.75 | MAPT (0.65) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL4049186 | 0.73 | MEN1 (0.52) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL4228405 | 0.71 | HSD17B10 (0.45) | MEN1KMT2AMAPTNPSR1L3MBTL1 | |
| SCHEMBL4230926 | 0.71 | CSNK1D (0.46) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL300887 | 0.69 | LMNA (0.51) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL29557517 | 0.69 | HSD17B10 (0.52) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL4467732 | 0.68 | MAPK1 (0.56) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL4363788 | 0.67 | KMT2A (0.50) | MEN1KMT2AMAPTNPSR1L3MBTL1 | |
| SCHEMBL13299337 | 0.65 | KMT2A (0.49) | MEN1KMT2AMAPTNPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | Signal Pharmaceuticals LLC (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008051494-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-05-02 | — | — | WO | disclosed |