SCHEMBL4467732

SCHEMBL4467732

COc1ccccc1-c1nc(-c2ccccc2O)nc(-c2ccccc2OC)n1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 3/20 0.56
TSHR P16473 4/20 0.55
TP53 P04637 4/20 0.55
CA1 P00915 1/20 0.55
CA2 P00918 1/20 0.55
KMT2A Q03164 7/20 0.55
MAPT P10636 5/20 0.55
MEN1 O00255 5/20 0.55
NPSR1 Q6W5P4 2/20 0.55
SMN1; SMN2 Q16637 4/20 0.52
ALDH1A1 P00352 7/20 0.50
LMNA P02545 6/20 0.49
CYP3A4 P08684 4/20 0.49
HSD17B10 Q99714 4/20 0.49
ALOX15 P16050 3/20 0.49
CYP1A2 P05177 3/20 0.49
CYP2D6 P10635 3/20 0.49
ADORA3 P0DMS8 2/20 0.49
KDM4E B2RXH2 2/20 0.49
USP2 O75604 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4455855 0.92 TSHR (0.62) MAPK1TSHRTP53CA1CA2
SCHEMBL13299337 0.92 KMT2A (0.49) MAPK1TSHRTP53CA1CA2
SCHEMBL4021180 0.89 TSHR (0.59) MAPK1TSHRTP53CA1CA2
SCHEMBL23066466 0.88 ALDH1A1 (0.61) MAPK1TSHRTP53CA1CA2
SCHEMBL12216379 0.88 NPC1 (0.51) MAPK1TSHRTP53KMT2AMAPT
SCHEMBL15005350 0.86 SIRT5 (0.58) MAPK1TSHRTP53KMT2AMAPT
SCHEMBL15005603 0.84 NPC1 (0.55) MAPK1TSHRTP53KMT2AMAPT
SCHEMBL16790688 0.83 ADORA3 (0.46) MAPK1TSHRTP53CA2KMT2A
SCHEMBL9488528 0.83 MAPK1 (0.58) MAPK1TSHRKMT2AMAPTMEN1
SCHEMBL4398788 0.82 TP53 (0.67) MAPK1TSHRTP53CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170189277-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF L'OREAL (FR) 2017-07-06 US disclosed
US-20170189277-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF L'OREAL (FR) 2017-07-06 US disclosed
US-9669243-B2 Delivery of hydrophobic benefit agents from bodywashes and the like onto a keratinous substrate BASF SE (DE) 2017-06-06 US disclosed
US-20150190320-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES L'OREAL (FR) 2015-07-09 US disclosed
US-20150190320-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES L'OREAL (FR) 2015-07-09 US disclosed
US-20150157539-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES L'OREAL (FR) 2015-06-11 US disclosed
US-20150157539-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES L'OREAL (FR) 2015-06-11 US disclosed
US-8882902-B2 Composite pigment and method for preparation thereof L'OREAL (FR) 2014-11-11 US disclosed
US-8882902-B2 Composite pigment and method for preparation thereof L'OREAL (FR) 2014-11-11 US disclosed
US-20130309285-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF L'OREAL (FR) 2013-11-21 US disclosed
WO-2008122516-A2 SUNSCREEN AND PERSONAL CARE COMPOSITIONS COMPRISING A SELECT COPOLYMER BASF SE (CH) 2008-10-16 WO disclosed
WO-2008122517-A2 SUNSCREEN COMPOSITIONS COMPRISING A RANDOM TERPOLYMER BASF SE (CH) 2008-10-16 WO disclosed
US-20080247976-A1 water-resistant cosmetic or dermatological compositions for the UV-photoprotection of human skin and/or hair with enhanced stability to water DUEVA-KOGANOV OLGA V 2008-10-09 US disclosed
US-20080247975-A1 Sunscreen and personal care compositions comprising a select copolymer CIBA CORP. 2008-10-09 US disclosed
US-20080089853-A1 Amphoteric Ethyl Methacrylate Copolymers and Use Thereof BASF AKTIENGESELLSCHAFT (DE) 2008-04-17 US disclosed
US-20080019929-A1 Micro-Particulate Organic Uv Absorber Composition CIBA SPECIALTY CHEMICALS CORP. 2008-01-24 US disclosed
EP-0658156-B1 HYDROXYPHENYL-S-TRIAZINES CIBA SC HOLDING AG (CH) 2002-10-09 EP disclosed
US-5942564-A OXIDATION AND HEAT RESISTANCE; PHOTOSTABILITY CIBA SPECIALTY CHEMICALS CORPORATION (US) 1999-08-24 US disclosed
EP-0658156-A1 HYDROXYPHENYL-S-TRIAZINES Ciba SC Holding AG (CH) 1995-06-21 EP disclosed
WO-1994005645-A1 HYDROXYPHENYL-S-TRIAZINES CIBA-GEIGY AG (CH) 1994-03-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080247976-A1 water-resistant cosmetic or dermatological compositions for the UV-photoprotection of human skin and/or hair with enhanced stability to water CUTA, POLR1C, MSH6 MAPK1 3506/4885TSHR 2856/4885TP53 25/4885
US-20080089853-A1 Amphoteric Ethyl Methacrylate Copolymers and Use Thereof MEP1A, ACMSD, MEP1B MAPK1 2568/4885TSHR 4833/4885TP53 1671/4885
US-20170189277-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF TYR, RAB5IF, MITF MAPK1 3362/4885TSHR 3682/4885TP53 337/4885
US-20080247975-A1 Sunscreen and personal care compositions comprising a select copolymer MSH6, CUTA, ERCC5 MAPK1 3695/4885TSHR 3904/4885TP53 21/4885
US-20150157539-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES MITF, RAB5IF, TYR MAPK1 3119/4885TSHR 1743/4885TP53 640/4885
US-20080019929-A1 Micro-Particulate Organic Uv Absorber Composition PCNA, FASN, CCNO MAPK1 3003/4885TSHR 2450/4885TP53 195/4885
US-20130309285-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF TYR, RAB5IF, MITF MAPK1 3362/4885TSHR 3682/4885TP53 337/4885
US-20150190320-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES XPA, ERCC1, ERCC4 MAPK1 3940/4885TSHR 2451/4885TP53 869/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.