Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | DUT | P33316 | 1/20 | 0.31 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056718 | 0.83 | KIF11 (0.41) | MAPTL3MBTL1ADORA3 | |
| SCHEMBL4050591 | 0.83 | KIF11 (0.41) | ADORA2AADORA2BADORA3 | |
| SCHEMBL4055834 | 0.83 | KIF11 (0.41) | ADORA2AADORA2BADORA3 | |
| SCHEMBL4056720 | 0.83 | KIF11 (0.41) | MAPTL3MBTL1ADORA3 | |
| SCHEMBL4054984 | 0.81 | KIF11 (0.39) | ADORA2AADORA3 | |
| SCHEMBL4054974 | 0.81 | KIF11 (0.39) | ADORA2AADORA3 | |
| SCHEMBL4049089 | 0.74 | KIF11 (0.39) | ADORA3 | |
| SCHEMBL4051429 | 0.74 | HPGD (0.43) | HPGDALDH1A1ADORA2AMAPTKDM4E | |
| SCHEMBL4050365 | 0.74 | HPGD (0.43) | HPGDALDH1A1ADORA2AMAPTKDM4E | |
| SCHEMBL4050872 | 0.74 | HPGD (0.43) | HPGDALDH1A1ADORA2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070932-A1 | Pyrazolotriazines | 4SC AG (DE) | 2009-06-17 | — | — | EP | disclosed |