Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 5/20 | 0.44 |
| ▸ | PPARD | Q03181 | 5/20 | 0.44 |
| ▸ | PPARA | Q07869 | 5/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TLR2 | O60603 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Octanedioate SCHEMBL4055395 | 0.95 | TSHR (0.57) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Octanedioate SCHEMBL4055387 | 0.95 | TSHR (0.57) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Glutarate SCHEMBL4060585 | 0.90 | SLC22A6 (0.58) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Succinic Acid SCHEMBL29181188 | 0.89 | LMNA (0.53) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Nonanoate SCHEMBL28289657 | 0.87 | GPR84 (0.68) | LMNATSHRSLC22A6GPR84FFAR1 | |
| Octanoic Acid SCHEMBL28240440 | 0.87 | GPR84 (0.68) | LMNATSHRSLC22A6GPR84FFAR1 | |
| Cyclohexene SCHEMBL19020155 | 0.84 | KDM4C (0.47) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Cyclohexene SCHEMBL28949429 | 0.84 | TSHR (0.64) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Dodecanoate SCHEMBL27802307 | 0.83 | GPR84 (0.68) | LMNATSHRSLC22A6GPR84FFAR1 | |
| Cyclohexene SCHEMBL28949419 | 0.82 | TSHR (0.62) | LMNATSHRNFKB1PMP22SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105622385-A | Process for preparing adipic acid through cleaning catalytic oxidation of cyclohexanone, catalyst, and catalyst preparation method | UNIV HUNAN NORMAL | 2016-06-01 | — | — | CN | disclosed |
| US-8946470-B2 | Method for the oxidation of unsaturated organic compounds | CATEXEL LIMITED (GB) | 2015-02-03 | — | — | US | disclosed |
| CN-103140463-A | Process for the oxidation of unsaturated organic compounds | UNILEVER PLC | 2013-06-05 | — | — | CN | disclosed |
| WO-2009109857-A1 | METHOD FOR PRODUCING CARBOXYLIC ACIDS BY OXIDATIVE CLEAVAGE OF UNSATURATED COMPOUNDS | UNIVERSITEIT LEIDEN (NL) | 2009-09-11 | — | — | WO | disclosed |