SCHEMBL4049989

SCHEMBL4049989

CN(Cc1ccccc1)c1ccc(C=O)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.52
CYP2A13 Q16696 1/20 0.52
NR1H2 P55055 1/20 0.50
NR1H3 Q13133 1/20 0.50
CRHBP P24387 1/20 0.49
CRHR2 Q13324 1/20 0.49
ALDH1A1 P00352 5/20 0.48
ALDH3A1 P30838 1/20 0.48
ALDH1A3 P47895 1/20 0.48
KDM4E B2RXH2 1/20 0.48
G6PC1 P35575 1/20 0.47
TSHR P16473 2/20 0.45
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
MCL1 Q07820 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
RAB9A P51151 2/20 0.44
CNR2 P34972 1/20 0.43
IP6K1 Q92551 1/20 0.43
AOC3 Q16853 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17508122 0.93 CRHBP (0.57) CYP2A6CYP2A13NR1H2NR1H3CRHBP
SCHEMBL11881187 0.84 NR1H2 (0.62) NR1H2NR1H3CRHBPCRHR2ALDH1A1
SCHEMBL4056353 0.84 CYP2A6 (0.55) CYP2A6CYP2A13CRHBPCRHR2ALDH1A1
SCHEMBL4048393 0.84 CYP2A6 (0.55) CYP2A6CYP2A13CRHBPCRHR2ALDH1A1
SCHEMBL4054714 0.83 CYP2A6 (0.48) CYP2A6CYP2A13CRHBPCRHR2ALDH1A1
SCHEMBL13242094 0.83 CYP2A6 (0.48) CYP2A6CYP2A13NR1H2NR1H3CRHBP
SCHEMBL1165356 0.81 CYP2C19 (0.58) CYP2A6CYP2A13NR1H2NR1H3CRHBP
SCHEMBL8620760 0.81 NR3C2 (0.49) CYP2A6CYP2A13ALDH1A1ALDH3A1ALDH1A3
SCHEMBL8484118 0.81 ACHE (0.52) CYP2A6ALDH1A1KDM4ETSHRSMN1; SMN2
SCHEMBL4050305 0.81 ALDH1A1 (0.49) CYP2A6CYP2A13NR1H2NR1H3CRHBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3006432-B1 2,3-BUTANEDIAMIDE EPOXIDE COMPOUND AND PREPARATION METHOD AND USE THEREOF INST PHARMACOLOGY & TOXICOLOGY ACAD MILITARY MEDICAL SCIENCES PLA CHINA (CN) 2017-11-15 EP disclosed
WO-2009109998-A1 NOVEL PROTEIN TYROSINE PHOSPHATASE - IB INHIBITORS LUPIN LIMITED (IN) 2009-09-11 WO disclosed
EP-0118086-B1 TWO-COMPONENT DIAZO TYPE MATERIAL HOECHST AKTIENGESELLSCHAFT (DE) 1989-09-27 EP disclosed
US-4732991-A Substituted phthalides HILTON DAVIS CHEMICAL CO. (US) 1988-03-22 US disclosed
US-4595768-A 3-(substituted phenyl)phthalides THE HILTON-DAVIS CHEMICAL CO. (US) 1986-06-17 US disclosed
EP-0074569-B1 CATIONIC METHINE DYES, PROCESS FOR THEIR PREPARATION AND THEIR USE, IN DYEING TEXTILE MATERIALS AND OTHER SUBSTRATES BAYER AG (DE) 1985-06-19 EP disclosed
US-4513142-A Preparation of cationic methine dyestuffs BAYER AKTIENGESELLSCHAFT (DE) 1985-04-23 US disclosed
US-4494989-A PRESSURE SENSITIVE CARBONLESS DUPLICATING OR THERMAL MARKING SYSTEMS THE HILTON-DAVIS CHEMICAL CO. (US) 1985-01-22 US disclosed
EP-0118086-A2 Two-component diazo type material HOECHST AKTIENGESELLSCHAFT (DE) 1984-09-12 EP disclosed
EP-0074569-A2 Cationic methine dyes, process for their preparation and their use, in dyeing textile materials and other substrates BAYER AG (DE) 1983-03-23 EP disclosed
US-4257954-A INDOLYL-PHENYLSULFONYL-PHENYL METHANE STERLING DRUG INC. (US) 1981-03-24 US disclosed
US-4110070-A QUATERNIZING INDOLENINE METHINE COMPOUND ON FIBERS TO FORM CATIONIC DYE HODOGAYA CHEMICAL CO., LTD. (JP) 1978-08-29 US disclosed