Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | USP1 | O94782 | 16/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15206153 | 0.78 | PIK3CA (0.59) | ADORA3MTORUSP1PIK3CD | |
| SCHEMBL300868 | 0.77 | PIK3CD (0.71) | PIK3CD | |
| SCHEMBL28028896 | 0.76 | PIK3CD (0.49) | MTORPIK3CD | |
| SCHEMBL4051247 | 0.75 | PIK3CD (0.43) | ADORA3PIK3CD | |
| SCHEMBL15206336 | 0.74 | JAK2 (0.55) | ADORA3MTORPIK3CD | |
| SCHEMBL29829189 | 0.74 | JAK2 (0.55) | ADORA3MTORPIK3CD | |
| SCHEMBL18865991 | 0.74 | USP1 (0.80) | USP1 | |
| SCHEMBL29691064 | 0.74 | USP1 (0.80) | USP1 | |
| SCHEMBL7215331 | 0.73 | ADORA3 (0.68) | ADORA3USP1 | |
| SCHEMBL4050613 | 0.72 | PIK3CA (0.53) | MTORUSP1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | Signal Pharmaceuticals LLC (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008051494-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-05-02 | — | — | WO | disclosed |