Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.49 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.47 |
| ▸ | FPR3 | P25089 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3986190 | 0.86 | KDM4E (0.53) | KDM4EPKMIDO1TDO2BCDIN3D | |
| SCHEMBL4052814 | 0.82 | GRIN2B (0.46) | KDM4EGRIN2BCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4460419 | 0.82 | IDO1 (0.53) | KDM4EPKMIDO1TDO2BCDIN3D | |
| SCHEMBL13690395 | 0.81 | GPR119 (0.56) | KDM4EPKMPRMT5GPR119GRIN2B | |
| SCHEMBL13893597 | 0.81 | IDO1 (0.53) | KDM4EPKMIDO1TDO2BCDIN3D | |
| SCHEMBL1874931 | 0.81 | FPR3 (0.47) | PRMT5FPR3FPR2KDM1A | |
| SCHEMBL19462008 | 0.81 | KDM4E (0.52) | KDM4EPKMIDO1TDO2BCDIN3D | |
| SCHEMBL1878430 | 0.81 | FPR3 (0.47) | PRMT5FPR3FPR2KDM1A | |
| SCHEMBL5353495 | 0.80 | BCDIN3D (0.50) | KDM4EPKMIDO1TDO2BCDIN3D | |
| SCHEMBL4056484 | 0.80 | KDM4E (0.52) | KDM4EPKMPRMT5GPR119GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |