Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4054310 | 0.88 | PDE10A (0.36) | HPGDKDM4EALDH1A1HSD17B10GAA | |
| SCHEMBL4371841 | 0.81 | HPGD (0.42) | RXFP1TP53HPGDPTK2BKDM4E | |
| SCHEMBL4527577 | 0.69 | PDE10A (0.43) | KDM4EALDH1A1LMNA | |
| SCHEMBL4055500 | 0.69 | KDM4E (0.39) | RXFP1HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL5022288 | 0.67 | KDM4E (0.49) | RXFP1HPGDKDM4EALDH1A1MAPT | |
| SCHEMBL28691180 | 0.65 | KDM4E (0.63) | HPGDKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL13920699 | 0.64 | HCAR2 (0.39) | ALDH1A1HSD17B10LMNAMAPK1TSHR | |
| SCHEMBL13920693 | 0.64 | KDM4E (0.43) | HPGDKDM4EALDH1A1HSD17B10GAA | |
| SCHEMBL13225526 | 0.64 | HCAR2 (0.43) | — | |
| SCHEMBL5026697 | 0.64 | ALKBH5 (0.59) | TP53HPGDKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115874-A2 | NOVEL HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-09-24 | — | — | WO | disclosed |