Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 2/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.35 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.35 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.34 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.32 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.32 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.31 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.31 |
| ▸ | CPB1 | P15086 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27482302 | 0.81 | SLC1A3 (0.33) | SLC7A5ADRA1ASLC1A3SLC1A2SLC1A1 | |
| SCHEMBL3968790 | 0.78 | RNPEP (0.46) | SLC7A5CACNA2D1CACNB3CACNA1CPGR | |
| SCHEMBL27928260 | 0.76 | TP53 (0.39) | GABRR1SLC7A5SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL11449757 | 0.76 | NAALAD2 (0.43) | GABRR1SLC7A5ENPEPRNPEP | |
| SCHEMBL27679365 | 0.74 | CTSK (0.33) | — | |
| SCHEMBL6706683 | 0.74 | CTSK (0.33) | — | |
| SCHEMBL27815325 | 0.74 | RNPEP (0.43) | SLC7A5SLC1A3SLC1A2SLC1A1ENPEP | |
| SCHEMBL11491423 | 0.73 | GABRR1 (0.52) | GABRR1SLC7A5CACNA2D1CACNB3CACNA1C | |
| SCHEMBL2868545 | 0.73 | GABRR1 (0.52) | GABRR1SLC7A5CACNA2D1CACNB3CACNA1C | |
| Acetic Acid SCHEMBL8630630 | 0.71 | GABBR2 (0.46) | GABRR1SLC7A5CACNA2D1CACNB3CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373344-B1 | COMBINED DRUG ADMINISTRATION | HOFFMANN LA ROCHE (CH) | 2016-03-30 | — | — | EP | claimed |
| WO-2009103164-A1 | ANTI-OBESITY COMPOSITIONS COMPRISING ORLISTAT AND VARIOUS NATURAL PRODUCTS | NORTHERN INNOVATIONS AND FORMULATIONS CORP. (CA) | 2009-08-27 | — | — | WO | disclosed |
| US-20090214682-A1 | Composition and methods for weight loss in a subject | IOVATE T & P. INC. (CA) | 2009-08-27 | — | — | US | disclosed |