SCHEMBL4052509

SCHEMBL4052509

COc1cccc(/C=C/C(=O)c2ccc(O)cc2O)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 8/20 1.00
NR1H4 Q96RI1 3/20 1.00
MAOA P21397 1/20 0.76
MAOB P27338 1/20 0.76
MAPT P10636 5/20 0.74
CYP3A4 P08684 5/20 0.74
MEN1 O00255 5/20 0.74
KMT2A Q03164 5/20 0.74
MAPK1 P28482 4/20 0.74
LMNA P02545 3/20 0.74
ALDH1A1 P00352 3/20 0.74
HPGD P15428 3/20 0.74
ALOX15 P16050 3/20 0.74
TP53 P04637 2/20 0.74
HSD17B10 Q99714 2/20 0.74
NPC1 O15118 1/20 0.74
RECQL P46063 1/20 0.74
RAB9A P51151 1/20 0.74
ATM Q13315 1/20 0.74
L3MBTL1 Q9Y468 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30384231 1.00 ABCG2 (1.00) ABCG2NR1H4MAOAMAOBMAPT
SCHEMBL4052514 1.00 ABCG2 (1.00) ABCG2NR1H4MAOAMAOBMAPT
SCHEMBL30384486 1.00 ABCG2 (1.00) ABCG2NR1H4MAOAMAOBMAPT
SCHEMBL5138658 0.95 ABCG2 (1.00) ABCG2NR1H4MAOAMAOBMAPT
SCHEMBL31233034 0.95 ABCG2 (1.00) ABCG2NR1H4MAOAMAOBMAPT
SCHEMBL5138657 0.95 ABCG2 (1.00) ABCG2NR1H4MAOAMAOBMAPT
SCHEMBL25185009 0.92 ABCG2 (0.90) ABCG2NR1H4MAOAMAOBMAPT
SCHEMBL21527675 0.92 ABCG2 (0.90) ABCG2NR1H4MAOAMAOBMAPT
SCHEMBL21527674 0.92 ABCG2 (0.90) ABCG2NR1H4MAOAMAOBMAPT
SCHEMBL14691342 0.91 NR1H4 (1.00) ABCG2NR1H4MAOAMAOBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed
US-9085520-B2 Composition for treating diabetes and metabolic diseases and a preparation method thereof KAOHSIUNG MEDICAL UNIVERSITY (TW) 2015-07-21 US disclosed
US-9085520-B2 Composition for treating diabetes and metabolic diseases and a preparation method thereof KAOHSIUNG MEDICAL UNIVERSITY (TW) 2015-07-21 US disclosed
US-9085520-B2 Composition for treating diabetes and metabolic diseases and a preparation method thereof KAOHSIUNG MEDICAL UNIVERSITY (TW) 2015-07-21 US disclosed
US-20140350304-A1 COMPOSITION FOR TREATING DIABETES AND METABOLIC DISEASES AND A PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2014-11-27 US disclosed
US-20140350304-A1 COMPOSITION FOR TREATING DIABETES AND METABOLIC DISEASES AND A PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2014-11-27 US disclosed
US-20140350304-A1 COMPOSITION FOR TREATING DIABETES AND METABOLIC DISEASES AND A PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2014-11-27 US disclosed
US-20140194474-A1 COMPOSITION FOR TREATING ATHEROSCLEROSIS AND A PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2014-07-10 US disclosed
US-20140194474-A1 COMPOSITION FOR TREATING ATHEROSCLEROSIS AND A PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2014-07-10 US disclosed
US-20130040996-A1 COMPOSITION FOR TREATING ATHEROSCLEROSIS AND A PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2013-02-14 US disclosed
US-20130040996-A1 COMPOSITION FOR TREATING ATHEROSCLEROSIS AND A PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2013-02-14 US disclosed
WO-2013022951-A1 COMPOSITION FOR TREATING DIABETES AND METABOLIC DISEASES AND A PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2013-02-14 WO disclosed
WO-2013022951-A1 COMPOSITION FOR TREATING DIABETES AND METABOLIC DISEASES AND A PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2013-02-14 WO disclosed
WO-2009026658-A1 PPAR AGONISTS THE UNIVERSITY OF SYDNEY (AU) 2009-03-05 WO disclosed
WO-2009026658-A1 PPAR AGONISTS THE UNIVERSITY OF SYDNEY (AU) 2009-03-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130040996-A1 COMPOSITION FOR TREATING ATHEROSCLEROSIS AND A PREPARATION METHOD THEREOF CDK4, PPARD, CCND1 ABCG2 2973/4885NR1H4 239/4885MAOA 4475/4885
US-20140194474-A1 COMPOSITION FOR TREATING ATHEROSCLEROSIS AND A PREPARATION METHOD THEREOF CDK4, PPARD, CCND1 ABCG2 2973/4885NR1H4 239/4885MAOA 4475/4885
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B ABCG2 1606/4885NR1H4 3875/4885MAOA 1902/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 ABCG2 3622/4885NR1H4 2983/4885MAOA 3145/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 ABCG2 3622/4885NR1H4 2983/4885MAOA 3145/4885
US-20140350304-A1 COMPOSITION FOR TREATING DIABETES AND METABOLIC DISEASES AND A PREPARATION METHOD THEREOF FABP1, GYS2, CYP7B1 ABCG2 186/4885NR1H4 323/4885MAOA 4277/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.