Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL992260 | 0.85 | — | — | |
| SCHEMBL27510109 | 0.85 | EPHX1 (0.39) | HSD11B1EPHX1DPP4 | |
| SCHEMBL583649 | 0.84 | — | — | |
| SCHEMBL5965337 | 0.84 | — | — | |
| SCHEMBL6476990 | 0.84 | — | — | |
| SCHEMBL4736940 | 0.83 | ALDH1A1 (0.36) | EPHX1DPP4 | |
| SCHEMBL16265413 | 0.83 | EPHX1 (0.35) | HSD11B1EPHX1DPP4 | |
| SCHEMBL7025316 | 0.83 | EPHX2 (0.36) | EPHX1BTK | |
| Water SCHEMBL6244435 | 0.83 | — | — | |
| SCHEMBL3525420 | 0.81 | EPHX2 (0.39) | EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081919-A1 | TETRAHYDROFURO [3, 2-B]PYRR0L-3-0NE INTERMEDIATES | Amura Therapeutics Limited (GB) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008007132-A1 | TETRAHYDROFURO [3, 2-B] PYRR0L-3-0NE INTERMEDIATES | AMURA THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |