Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 4/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.42 |
| ▸ | STAT6 | P42226 | 6/20 | 0.39 |
| ▸ | STAT5A | P42229 | 3/20 | 0.39 |
| ▸ | STAT5B | P51692 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4052986 | 0.94 | NPY5R (0.44) | NPY5RCCR1TRPV4STAT6STAT5A | |
| SCHEMBL4053906 | 0.93 | NPY5R (0.48) | NPY5RCCR1TRPV4STAT6STAT5A | |
| SCHEMBL4055537 | 0.93 | TRPV4 (0.41) | NPY5RCCR1TRPV4STAT6STAT5A | |
| SCHEMBL4050227 | 0.92 | STAT6 (0.41) | NPY5RCCR1TRPV4STAT6STAT5A | |
| SCHEMBL4056095 | 0.91 | TRPV4 (0.44) | NPY5RCCR1TRPV4STAT6STAT5A | |
| SCHEMBL4053522 | 0.91 | TRPV4 (0.51) | NPY5RCCR1TRPV4STAT6STAT5A | |
| SCHEMBL4051597 | 0.91 | TRPV4 (0.44) | NPY5RCCR1TRPV4STAT6STAT5A | |
| SCHEMBL4052453 | 0.91 | NPY5R (0.39) | NPY5RCCR1TRPV4STAT6STAT5A | |
| SCHEMBL4050524 | 0.90 | TRPV4 (0.42) | NPY5RCCR1TRPV4STAT6STAT5A | |
| SCHEMBL4058747 | 0.90 | CCR1 (0.41) | NPY5RCCR1TRPV4STAT6STAT5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | claimed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |