Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
| ▸ | STAT6 | P42226 | 6/20 | 0.39 |
| ▸ | STAT5A | P42229 | 3/20 | 0.39 |
| ▸ | STAT5B | P51692 | 2/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050524 | 0.93 | TRPV4 (0.42) | CCR1TRPV4STAT6STAT5ASTAT5B | |
| SCHEMBL4056095 | 0.90 | TRPV4 (0.44) | CCR1TRPV4STAT6STAT5ASTAT5B | |
| SCHEMBL4055537 | 0.90 | TRPV4 (0.41) | CCR1TRPV4STAT6STAT5ASTAT5B | |
| SCHEMBL4051597 | 0.90 | TRPV4 (0.44) | CCR1TRPV4STAT6STAT5ASTAT5B | |
| SCHEMBL4053522 | 0.90 | TRPV4 (0.51) | CCR1TRPV4STAT6STAT5ASTAT5B | |
| SCHEMBL4050589 | 0.90 | TRPV4 (0.44) | CCR1TRPV4STAT6STAT5ASTAT5B | |
| SCHEMBL4052860 | 0.90 | NPY5R (0.47) | CCR1TRPV4STAT6STAT5ASTAT5B | |
| SCHEMBL4052986 | 0.89 | NPY5R (0.44) | CCR1TRPV4STAT6STAT5ASTAT5B | |
| SCHEMBL4056979 | 0.89 | TRPV4 (0.44) | CCR1TRPV4STAT6STAT5ASTAT5B | |
| SCHEMBL4053892 | 0.88 | STAT6 (0.40) | CCR1TRPV4STAT6STAT5ASTAT5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | claimed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |