Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | STAT6 | P42226 | 5/20 | 0.38 |
| ▸ | STAT5A | P42229 | 3/20 | 0.38 |
| ▸ | STAT5B | P51692 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4052860 | 0.93 | NPY5R (0.47) | TRPV4CCR1NPY5ROPRM1STAT6 | |
| SCHEMBL4052986 | 0.93 | NPY5R (0.44) | TRPV4CCR1NPY5RSTAT6STAT5A | |
| SCHEMBL4050227 | 0.90 | STAT6 (0.41) | TRPV4CCR1NPY5RSTAT6STAT5A | |
| SCHEMBL4049802 | 0.90 | L3MBTL1 (0.44) | NPY5RSTAT6STAT5ASTAT5BNPC1 | |
| SCHEMBL4051597 | 0.90 | TRPV4 (0.44) | TRPV4CCR1NPY5ROPRM1STAT6 | |
| SCHEMBL4056095 | 0.90 | TRPV4 (0.44) | TRPV4CCR1NPY5ROPRM1STAT6 | |
| SCHEMBL4053522 | 0.90 | TRPV4 (0.51) | TRPV4CCR1NPY5ROPRM1STAT6 | |
| SCHEMBL4058747 | 0.90 | CCR1 (0.41) | TRPV4CCR1NPY5ROPRM1STAT6 | |
| SCHEMBL4050971 | 0.89 | STAT6 (0.37) | TRPV4CCR1NPY5RSTAT6STAT5A | |
| SCHEMBL4050524 | 0.89 | TRPV4 (0.42) | TRPV4CCR1NPY5ROPRM1STAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |