Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.35 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.35 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.35 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19856906 | 0.88 | DRD2 (0.45) | STAT6DRD2DRD3TAS1R3TAS1R1 | |
| SCHEMBL8012381 | 0.86 | DRD3 (0.41) | STAT6DRD2DRD3TAS1R3TAS1R1 | |
| SCHEMBL19856869 | 0.82 | DRD2 (0.43) | STAT6DRD2TAS1R3TAS1R1CYP51A1 | |
| SCHEMBL19856870 | 0.82 | DRD2 (0.43) | STAT6DRD2TAS1R3TAS1R1CYP51A1 | |
| SCHEMBL1549547 | 0.82 | PDGFRB (0.46) | STAT6DRD2CYP51A1AKR1C3NPC1 | |
| SCHEMBL4050835 | 0.81 | DRD2 (0.39) | STAT6DRD2TAS1R3TAS1R1CYP51A1 | |
| SCHEMBL19856987 | 0.81 | STAT6 (0.41) | STAT6DRD2TAS1R3TAS1R1CYP51A1 | |
| SCHEMBL1931303 | 0.80 | DRD2 (0.47) | STAT6DRD2TAS1R3TAS1R1CYP51A1 | |
| SCHEMBL1931738 | 0.80 | DRD2 (0.47) | STAT6DRD2TAS1R3TAS1R1CYP51A1 | |
| SCHEMBL14964347 | 0.80 | DRD2 (0.47) | STAT6DRD2TAS1R3TAS1R1CYP51A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | claimed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |