Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.52 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1408409 | 0.85 | GRN (0.55) | PTGS2PTGS1NPC1TP53MAPT | |
| SCHEMBL31420366 | 0.84 | PTGS2 (0.58) | PTGS2PTGS1KLKB1MAPTHDAC3 | |
| SCHEMBL22143177 | 0.83 | PTGS1 (0.56) | PTGS2PTGS1MAPTSMN1; SMN2HDAC3 | |
| SCHEMBL25249559 | 0.82 | PTGS2 (0.57) | PTGS2PTGS1KLKB1MAPTHDAC3 | |
| SCHEMBL1012734 | 0.81 | PTGS1 (0.63) | PTGS2PTGS1KLKB1NPC1TP53 | |
| SCHEMBL2083765 | 0.80 | ALDH1A1 (0.53) | PTGS1MAPTSMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL1013645 | 0.80 | PTGS2 (0.55) | PTGS2PTGS1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4247328 | 0.79 | PTGS2 (0.74) | PTGS2PTGS1TP53MAPTSMN1; SMN2 | |
| SCHEMBL31255079 | 0.79 | PTGS2 (0.54) | PTGS2PTGS1KLKB1MAPTSMN1; SMN2 | |
| SCHEMBL1013244 | 0.78 | CYP2C9 (0.57) | PTGS2PTGS1NPC1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836173-A4 | ANTI-INFLAMMATORY MEDICAMENTS | DECIPHERA PHARMACEUTICALS LLC (US) | 2009-07-08 | — | — | EP | disclosed |
| EP-1836173-A2 | ANTI-INFLAMMATORY MEDICAMENTS | Deciphera Pharmaceuticals, LLC (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006081034-A2 | ANTI-INFLAMMATORY MEDICAMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2006-08-03 | — | — | WO | disclosed |