Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 7/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.49 |
| ▸ | AURKA | O14965 | 4/20 | 0.45 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055484 | 0.85 | TBK1 (0.66) | IKBKETBK1AURKAAURKBCDK2 | |
| SCHEMBL4062213 | 0.84 | ADORA2A (0.40) | IKBKETBK1P2RY6GABRA1GABRG2 | |
| SCHEMBL4059593 | 0.84 | IKBKE (0.47) | IKBKETBK1AURKAP2RY6 | |
| SCHEMBL4059384 | 0.83 | AURKA (0.55) | IKBKETBK1AURKATRPV1AURKB | |
| SCHEMBL13608020 | 0.83 | P2RY6 (0.43) | P2RY6TRPV1CDK2GABRA1GABRG2 | |
| SCHEMBL4050957 | 0.82 | IKBKE (0.49) | IKBKETBK1AURKA | |
| SCHEMBL4064138 | 0.81 | TBK1 (0.52) | IKBKETBK1AURKAAURKBCDK2 | |
| SCHEMBL4062911 | 0.81 | IKBKE (0.48) | IKBKETBK1AURKACHEK2 | |
| SCHEMBL4239405 | 0.80 | GABRA1 (0.43) | IKBKETBK1AURKAAURKBBRAF | |
| SCHEMBL4061866 | 0.80 | AURKA (0.57) | IKBKETBK1AURKAAURKBCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-20050101647-A1 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-05-12 | — | — | US | disclosed |
| EP-1460067-A1 | BICYCLIC DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE | Takeda Chemical Industries, Ltd. (JP) | 2004-09-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101647-A1 | Bicyclic derivative, its production and use | ABL1, SRC, PTK2B | IKBKE 129/4885TBK1 1212/4885AURKA 247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.