Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2892482 | 0.82 | GRM5 (0.43) | GRM5KCNH2HRH3MEN1KMT2A | |
| SCHEMBL2290995 | 0.79 | GRM5 (0.44) | GRM5KCNH2HRH3MEN1KMT2A | |
| SCHEMBL8675743 | 0.75 | GRM5 (0.49) | GRM5MEN1KMT2A | |
| SCHEMBL14812990 | 0.75 | GRM5 (0.36) | GRM5KCNH2HRH3MEN1KMT2A | |
| SCHEMBL4538188 | 0.75 | GRM5 (0.36) | GRM5KCNH2HRH3MEN1KMT2A | |
| SCHEMBL28811006 | 0.73 | GRM5 (0.47) | GRM5ALDH1A1SMN1; SMN2 | |
| SCHEMBL2285672 | 0.73 | GRM5 (0.42) | GRM5ALDH1A1SMN1; SMN2 | |
| SCHEMBL25310964 | 0.70 | GRM5 (0.49) | GRM5 | |
| SCHEMBL5796435 | 0.70 | GRM5 (0.57) | GRM5 | |
| SCHEMBL4536276 | 0.70 | GRM5 (0.40) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732903-B1 | TRIAZOLONE DERIVATIVES AS MMP INHIBITORS FOR THE TREATMENT OF ASTHMA AND COPD | ASTRAZENECA AB (SE) | 2009-02-18 | — | — | EP | disclosed |