Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GPX4 | P36969 | 1/20 | 0.30 |
| ▸ | QDPR | P09417 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31558715 | 0.89 | GRM5 (0.43) | GRM5DRD2DRD4DRD3SMN1; SMN2 | |
| SCHEMBL31558707 | 0.88 | GRM5 (0.42) | GRM5DRD2DRD4DRD3 | |
| SCHEMBL31558712 | 0.85 | GRM5 (0.40) | GRM5DRD2DRD4DRD3MEN1 | |
| SCHEMBL2892482 | 0.83 | GRM5 (0.43) | GRM5ALDH1A1SMN1; SMN2KCNH2HRH3 | |
| SCHEMBL31558705 | 0.83 | NAMPT (0.39) | GRM5DRD2DRD4DRD3 | |
| SCHEMBL31558699 | 0.83 | NAMPT (0.39) | GRM5DRD2DRD4DRD3 | |
| SCHEMBL30858355 | 0.83 | AKR1C3 (0.40) | GRM5ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL5796435 | 0.82 | GRM5 (0.57) | GRM5 | |
| SCHEMBL3348910 | 0.82 | GRM5 (0.66) | GRM5SMN1; SMN2 | |
| SCHEMBL31558708 | 0.82 | GRM5 (0.42) | GRM5ALDH1A1SMN1; SMN2KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989620-B2 | Hydantoin derivatives for the treatment of obstructive airway diseases | ASTRAZENECA AB (SE) | 2011-08-02 | — | — | US | disclosed |
| US-20100144771-A1 | Novel Hydantoin Derivatives for the Treatment of Obstructive Airway Diseases | ASTRAZENECA AB (SE) | 2010-06-10 | — | — | US | disclosed |
| US-7648992-B2 | Hydantoin derivatives for the treatment of obstructive airway diseases | ASTRAZENECA AB (SE) | 2010-01-19 | — | — | US | disclosed |
| US-20090299066-A1 | TRIAZOLONE DERIVATIVES AS MMP INHIBITORS FOR THE TREATMENT OF ASTHMA AND COPD | ERIKSSON ANDERS | 2009-12-03 | — | — | US | disclosed |
| EP-1778673-B1 | NOVEL HYDANTOIN DERIVATIVES FOR THE TREATMENT OF OBSTRUCTIVE AIRWAY DISEASES | ASTRAZENECA AB (SE) | 2009-11-11 | — | — | EP | disclosed |
| CN-100543024-C | The hydantoin derivatives that is used for the treatment of obstructive airway diseases | ASTRAZENECA AB (SE) | 2009-09-23 | — | — | CN | disclosed |
| EP-1732903-B1 | TRIAZOLONE DERIVATIVES AS MMP INHIBITORS FOR THE TREATMENT OF ASTHMA AND COPD | ASTRAZENECA AB (SE) | 2009-02-18 | — | — | EP | disclosed |
| EP-1638491-A4 | DEPLOYABLE MULTIFUNCTIONAL HEMOSTATIC AGENT | UNIV LOMA LINDA MED (US) | 2008-05-28 | — | — | EP | disclosed |
| US-20080064710-A1 | Novel Hydantoin Derivatives for the Treatment of Obstructive Airway Diseases | ASTRAZENECA AB (SE) | 2008-03-13 | — | — | US | disclosed |
| US-20070219217-A1 | Triazolone Derivatives as Mmp Inhibitors for the Treatment of Asthma and Copd | ASTRAZENECA AB (SE) | 2007-09-20 | — | — | US | disclosed |
| CN-1980914-A | Novel hydantoin derivatives for the treatment of obstructive airway diseases. | ASTRAZENECA AB (SE) | 2007-06-13 | — | — | CN | disclosed |
| CN-1960979-A | Triazolone derivatives as MMP inhibitors for the treatment of asthma and copd | ASTRAZENECA AB (SE) | 2007-05-09 | — | — | CN | disclosed |
| EP-1638491-A2 | DEPLOYABLE MULTIFUNCTIONAL HEMOSTATIC AGENT | Loma Linda University Medical Center (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005002510-A2 | DEPLOYABLE MULTIFUNCTIONAL HEMOSTATIC AGENT | LOMA LINDA UNIVERSITY MEDICAL CENTER (US) | 2005-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219217-A1 | Triazolone Derivatives as Mmp Inhibitors for the Treatment of Asthma and Copd | MMP9, MMP3, MMP25 | GRM5 2004/4885DRD2 1910/4885DRD4 2005/4885 |
| US-20090299066-A1 | TRIAZOLONE DERIVATIVES AS MMP INHIBITORS FOR THE TREATMENT OF ASTHMA AND COPD | MMP3, MMP9, MMP25 | GRM5 1923/4885DRD2 1977/4885DRD4 2201/4885 |
| US-20080064710-A1 | Novel Hydantoin Derivatives for the Treatment of Obstructive Airway Diseases | HRH4, HRH1, HRH2 | GRM5 2437/4885DRD2 2371/4885DRD4 3693/4885 |
| US-20100144771-A1 | Novel Hydantoin Derivatives for the Treatment of Obstructive Airway Diseases | HRH4, HRH1, HRH2 | GRM5 2364/4885DRD2 2473/4885DRD4 3786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.