Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 0.57 |
| ▸ | GRM1 | Q13255 | 10/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348910 | 0.91 | GRM5 (0.66) | GRM5GRM1PDK4JAK1ESR2 | |
| SCHEMBL2891556 | 0.86 | GRM5 (0.58) | GRM5GRM1PDK4JAK1ESR2 | |
| SCHEMBL2290995 | 0.82 | GRM5 (0.44) | GRM5 | |
| SCHEMBL2893138 | 0.77 | GRM5 (0.63) | GRM5GRM1PDK4JAK1ESR2 | |
| SCHEMBL4538188 | 0.77 | GRM5 (0.36) | GRM5 | |
| SCHEMBL14995149 | 0.75 | GRM5 (0.70) | GRM5GRM1PDK4ESR2NAMPT | |
| SCHEMBL20001581 | 0.74 | GRM5 (0.60) | GRM5GRM1PDK4JAK1ESR2 | |
| SCHEMBL25310964 | 0.74 | GRM5 (0.49) | GRM5GRM1PDK4JAK1ESR2 | |
| SCHEMBL19989696 | 0.74 | GRM5 (0.69) | GRM5GRM1PDK4ESR2NAMPT | |
| SCHEMBL2893109 | 0.73 | GRM5 (0.58) | GRM5GRM1PDK4JAK1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732903-A1 | TRIAZOLONE DERIVATIVES AS MMP INHIBITORS FOR THE TREATMENT OF ASTHMA AND COPD | AstraZeneca AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005095362-A1 | TRIAZOLONE DERIVATIVES AS MMP INHIBITORS FOR THE TREATMENT OF ASTHMA AND COPD | ASTRAZENECA AB (SE) | 2005-10-13 | — | — | WO | disclosed |