Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.58 |
| ▸ | CXCL8 | P10145 | 4/20 | 0.58 |
| ▸ | TTR | P02766 | 3/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.58 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.58 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.58 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.58 |
| ▸ | ALB | P02768 | 1/20 | 0.58 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.58 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.58 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.58 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.58 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.58 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.58 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.58 |
| ▸ | UGT1A10 | Q9HAW8 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13653119 | 0.86 | PTGS2 (0.61) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| SCHEMBL21724927 | 0.83 | PTGS2 (0.62) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| SCHEMBL4558747 | 0.83 | TAAR1 (0.58) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| SCHEMBL13909059 | 0.83 | PTGS2 (0.58) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| SCHEMBL9641224 | 0.80 | PTGS2 (0.63) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| SCHEMBL3805962 | 0.80 | PTGS2 (0.51) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| SCHEMBL3807421 | 0.79 | TAAR1 (0.62) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| SCHEMBL764380 | 0.79 | PTGS2 (0.66) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| SCHEMBL31325350 | 0.79 | PTGS2 (0.66) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| SCHEMBL13653118 | 0.79 | PTGS2 (0.61) | PTGS2CXCL8TTRPTGS1AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667770-B1 | METHOD FOR THE PRODUCTION OF DERIVATIVES OF 4A,5,9,10,11,12-HEXAHYDROBENZOFURO [3A,3,2][ 2]- BENZAZEPINE | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2009-03-11 | — | — | EP | disclosed |
| US-20070105837-A1 | Novel derivatives of 4a,5,9,10,11,12-hexahydrobenzofuro[3a,3,2][2]-benzazepine, method for the production thereof and use thereof in the production of medicaments | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2007-05-10 | — | — | US | disclosed |
| EP-1667770-A2 | NOVEL DERIVATIVES OF 4A,5,9,10,11,12-HEXAHYDROBENZOFURO [3A,3,2][ 2]- BENZAZEPINE, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF IN THE PRODUCTION OF MEDICAMENTS | Sanochemia Pharmazeutica Aktiengesellschaft (AT) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005030333-A2 | NOVEL DERIVATIVES OF 4A,5,9,10,11,12-HEXAHYDROBENZOFURO[3A,3,2] [2]- BENZAZEPINE, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF IN THE PRODUCTION OF MEDICAMENTS | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105837-A1 | Novel derivatives of 4a,5,9,10,11,12-hexahydrobenzofuro[3a,3,2][2]-benzazepine, method for the production thereof and use thereof in the production of medicaments | CYP4B1, CYP4Z1, HTR3C | PTGS2 1626/4885CXCL8 4538/4885TTR 3668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.