Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | MYLK | Q15746 | 4/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4058008 | 0.89 | PDE4A (0.33) | MYLKPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13693694 | 0.83 | PDE4A (0.41) | KDRPABPC1MYLKPDE4APDE4B | |
| SCHEMBL4532072 | 0.80 | MAOA (0.39) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL4532071 | 0.80 | MAOA (0.39) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL4062215 | 0.76 | KDR (0.34) | KDRPABPC1MYLKHPGDTP53 | |
| SCHEMBL4051543 | 0.75 | KDR (0.32) | KDRPABPC1MYLKHPGDTP53 | |
| SCHEMBL4059651 | 0.75 | KDR (0.35) | KDRMYLKPDE4APDE4BPDE4C | |
| SCHEMBL4054949 | 0.75 | TNKS (0.37) | KDRPABPC1MYLKHPGDKDM4E | |
| SCHEMBL4060742 | 0.74 | HSD17B10 (0.32) | KDRMYLKHPGDTP53KDM4E | |
| SCHEMBL4054950 | 0.74 | KDM4E (0.32) | KDRMYLKHPGDTP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115874-A2 | NOVEL HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-09-24 | — | — | WO | disclosed |