Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 5/20 | 0.40 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | DRD4 | P21917 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055092 | 0.80 | SIGMAR1 (0.39) | MAPTLMNAALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4056113 | 0.79 | SLC6A2 (0.42) | DRD3DRD2NAMPTLMNADRD4 | |
| SCHEMBL4944198 | 0.79 | SLC6A2 (0.36) | ALDH1A1POLB | |
| SCHEMBL4062006 | 0.76 | SLC6A2 (0.41) | DRD3DRD2DRD4 | |
| SCHEMBL4943708 | 0.73 | SLC6A2 (0.43) | DRD3DRD2LMNADRD4KMT2A | |
| SCHEMBL3615339 | 0.73 | SLC6A2 (0.40) | — | |
| SCHEMBL4053143 | 0.72 | SLC6A2 (0.42) | DRD3DRD2NAMPTLMNANPSR1 | |
| SCHEMBL4947338 | 0.72 | SLC6A2 (0.43) | ALDH1A1 | |
| SCHEMBL4053529 | 0.72 | SLC6A2 (0.54) | DRD3DRD2 | |
| SCHEMBL4940915 | 0.72 | SLC6A2 (0.46) | DRD3DRD2NAMPTLMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |