Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055089 | 0.90 | SLC6A2 (0.46) | SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL4065304 | 0.82 | SIGMAR1 (0.36) | SIGMAR1ALDH1A1MAPTKMT2ASLC6A2 | |
| SCHEMBL4055886 | 0.81 | SLC6A2 (0.42) | SLC6A2SLC6A4 | |
| SCHEMBL4055095 | 0.80 | DRD3 (0.40) | ALDH1A1MAPTKMT2ALMNASMN1; SMN2 | |
| SCHEMBL4943921 | 0.77 | SLC6A2 (0.40) | SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL4060071 | 0.77 | SLC6A2 (0.46) | SLC6A2SLC6A4 | |
| SCHEMBL4062000 | 0.77 | KDM4E (0.38) | ALDH1A1KMT2ASLC6A2KDM4EL3MBTL1 | |
| SCHEMBL4944198 | 0.77 | SLC6A2 (0.36) | ALDH1A1SLC6A2L3MBTL1SLC6A4 | |
| SCHEMBL4056101 | 0.76 | SLC6A2 (0.42) | KMT2ASLC6A2KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL4055078 | 0.76 | SLC6A2 (0.35) | ALDH1A1KMT2ASLC6A2KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |