Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2851081 | 0.94 | DRD2 (0.47) | MAPTTP53DRD3SMN1; SMN2MAPK1 | |
| SCHEMBL4057335 | 0.94 | DRD3 (0.52) | DRD3HTR1ADRD2HSD17B10HTR2A | |
| SCHEMBL2853060 | 0.94 | DRD2 (0.49) | MAPTTP53DRD3SMN1; SMN2MAPK1 | |
| SCHEMBL2194852 | 0.92 | DRD3 (0.53) | DRD3HTR1ADRD2HSD17B10HTR2A | |
| SCHEMBL2850938 | 0.92 | DRD2 (0.44) | MAPTTP53SMN1; SMN2MAPK1HTR1A | |
| SCHEMBL2194249 | 0.92 | DRD3 (0.53) | DRD3HTR1ADRD2HSD17B10HTR2A | |
| SCHEMBL2193588 | 0.90 | DRD2 (0.51) | DRD3HTR1AKDM4EDRD2HSD17B10 | |
| SCHEMBL4057154 | 0.82 | KDM4E (0.47) | DRD3HTR1AKDM4EDRD2HSD17B10 | |
| SCHEMBL4561888 | 0.81 | HRH3 (0.40) | MAPTDRD3HTR1ADRD2HTR2A | |
| SCHEMBL3258946 | 0.81 | KDM4E (0.47) | DRD3MAPK1HTR1AKDM4EDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1715921-A4 | TETRAHYDROINDOLONE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL CONDITIONS | ABRAXIS BIOSCIENCE INC (US) | 2009-07-15 | — | — | EP | disclosed |
| EP-1715921-A2 | TETRAHYDROINDOLONE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL CONDITIONS | Cenomed, Inc. (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005030148-A2 | TETRAHYDROINDOLONE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL CONDITIONS | CENOMED, INC. (US) | 2005-04-07 | — | — | WO | disclosed |