Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 6/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856627 | 0.98 | HRH3 (0.40) | HRH3KCNH2DRD3CHRM4HTR7 | |
| SCHEMBL2849035 | 0.96 | HTR7 (0.41) | HRH3KCNH2DRD3CHRM4HTR7 | |
| SCHEMBL2852974 | 0.96 | HRH3 (0.42) | HRH3KCNH2CHRM4HTR1AMCHR1 | |
| SCHEMBL4054287 | 0.87 | HTR7 (0.38) | HRH3DRD3HTR7DRD2HTR1A | |
| SCHEMBL4057335 | 0.87 | DRD3 (0.52) | DRD3HTR7DRD2HTR1AHTR2A | |
| SCHEMBL4050945 | 0.86 | HTR7 (0.48) | DRD3HTR7DRD2HTR1AHTR2A | |
| SCHEMBL3258946 | 0.86 | KDM4E (0.47) | DRD3DRD2HTR1AHTR2AHRH1 | |
| SCHEMBL2195868 | 0.85 | HTR7 (0.47) | DRD3HTR7DRD2HTR1AHTR2A | |
| SCHEMBL2194249 | 0.85 | DRD3 (0.53) | DRD3HTR7DRD2HTR1AHTR2A | |
| SCHEMBL2197706 | 0.84 | KDM4E (0.48) | DRD3DRD2HTR1AHTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1715921-A4 | TETRAHYDROINDOLONE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL CONDITIONS | ABRAXIS BIOSCIENCE INC (US) | 2009-07-15 | — | — | EP | disclosed |
| EP-1715921-A2 | TETRAHYDROINDOLONE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL CONDITIONS | Cenomed, Inc. (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005030148-A2 | TETRAHYDROINDOLONE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL CONDITIONS | CENOMED, INC. (US) | 2005-04-07 | — | — | WO | disclosed |