Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 5/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HRH1 | P35367 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2197706 | 0.98 | KDM4E (0.48) | KDM4ELMNAMAPK1HTR1ADRD2 | |
| SCHEMBL1256145 | 0.96 | HTR1A (0.49) | KDM4ELMNAMAPK1HTR1ADRD2 | |
| SCHEMBL2194422 | 0.96 | HTR1A (0.47) | KDM4ELMNAMAPK1HTR1ADRD2 | |
| SCHEMBL2196809 | 0.94 | HTR1A (0.48) | KDM4ELMNAMAPK1HTR1ADRD2 | |
| SCHEMBL4057154 | 0.88 | KDM4E (0.47) | KDM4EHTR1ADRD2HTR2AHRH1 | |
| SCHEMBL4050945 | 0.88 | HTR7 (0.48) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL2195337 | 0.87 | SLC6A2 (0.43) | KDM4EHTR1ADRD2ADRA1DADRA1A | |
| SCHEMBL2192247 | 0.87 | ALDH1A1 (0.46) | KDM4EHTR1ADRD2ADRA1DADRA1A | |
| SCHEMBL2194931 | 0.87 | KDM4E (0.47) | KDM4EHTR1ADRD2HTR2AHRH1 | |
| SCHEMBL4057335 | 0.86 | DRD3 (0.52) | HTR1ADRD2HTR2ADRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036395-A2 | TREATMENT OF ORGANOPHOSPHATE EXPOSURE WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS | CENOMED BIOSCIENCES, LLC (US) | 2010-04-01 | — | — | WO | disclosed |
| EP-1715921-A4 | TETRAHYDROINDOLONE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL CONDITIONS | ABRAXIS BIOSCIENCE INC (US) | 2009-07-15 | — | — | EP | disclosed |
| EP-1715921-A2 | TETRAHYDROINDOLONE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL CONDITIONS | Cenomed, Inc. (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005030148-A2 | TETRAHYDROINDOLONE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL CONDITIONS | CENOMED, INC. (US) | 2005-04-07 | — | — | WO | disclosed |