Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13905159 | 0.90 | PIK3CG (0.53) | PIK3CAMAPK8MAPK9MAPK10MAPK1 | |
| SCHEMBL4049544 | 0.85 | ABL1 (0.51) | PIK3CAMAPK8MAPK9MAPK10MAPK1 | |
| SCHEMBL13905321 | 0.83 | PIK3CA (0.50) | PIK3CAPIK3CG | |
| SCHEMBL12708163 | 0.79 | PIK3CA (0.67) | PIK3CAMAPK8MAPK9MAPK10MAPK1 | |
| SCHEMBL13905328 | 0.78 | PIK3CA (0.37) | PIK3CAMAPK8MAPK9MAPK10MAPK1 | |
| SCHEMBL12664153 | 0.76 | PIK3CG (0.48) | PIK3CAMAPK8DYRK1BRIPK1PIK3CG | |
| SCHEMBL12664385 | 0.76 | PIK3CA (0.54) | PIK3CARIPK1PIK3CG | |
| SCHEMBL1553208 | 0.74 | PIK3CA (0.65) | PIK3CAMAPK8MAPK9MAPK10MAPK1 | |
| SCHEMBL12664788 | 0.74 | RIPK1 (0.46) | PIK3CAMAPK8MAPK9MAPK10MAPK1 | |
| SCHEMBL1553258 | 0.73 | PIK3CA (0.60) | PIK3CAMAPK8MAPK9MAPK10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009027733-A1 | (2-PYRIDIN-3-YLIMIDAZO[1,2-B]PYRIDAZIN-6-YL) UREA DERIVATIVES AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2009-03-05 | — | — | WO | disclosed |
| WO-2009027733-A1 | (2-PYRIDIN-3-YLIMIDAZO[1,2-B]PYRIDAZIN-6-YL) UREA DERIVATIVES AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2009-03-05 | — | — | WO | disclosed |