Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.49 |
| ▸ | FEN1 | P39748 | 6/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | MPL | P40238 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1934910 | 0.81 | S1PR1 (0.43) | APPS1PR1PDE2A | |
| SCHEMBL5121382 | 0.79 | APP (0.57) | APPFEN1ALOX5APKIF11MPL | |
| SCHEMBL133385 | 0.77 | S1PR1 (0.60) | S1PR1KIF11 | |
| SCHEMBL27586620 | 0.76 | APP (0.54) | APPFEN1ALOX5APKIF11MPL | |
| SCHEMBL1935103 | 0.74 | TRPA1 (0.44) | IDO1 | |
| SCHEMBL4649439 | 0.73 | RORC (0.54) | APPFEN1ALOX5APKIF11AKR1C3 | |
| SCHEMBL13743069 | 0.73 | KIF11 (0.65) | APPFEN1ALOX5APKIF11 | |
| SCHEMBL4418949 | 0.72 | APP (0.54) | APPFEN1ALOX5APKIF11MPL | |
| SCHEMBL16900276 | 0.72 | APP (0.57) | APPFEN1ALOX5APKIF11AKR1C3 | |
| SCHEMBL1934713 | 0.71 | TRPA1 (0.46) | S1PR1KIF11IDO1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009120655-A1 | INDOLE DERIVATIVES | H. LUNDBECK A/S (DK) | 2009-10-01 | — | — | WO | disclosed |