Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.45 |
| ▸ | PYGL | P06737 | 2/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | CYP51A1 | Q16850 | 4/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057132 | 0.90 | TRPV4 (0.49) | TAS1R3TAS1R1TRPV4PYGLCTNNB1 | |
| SCHEMBL4057362 | 0.89 | PYGL (0.39) | PYGLCYP51A1DRD3 | |
| SCHEMBL4049305 | 0.88 | TRPV4 (0.42) | TRPV4LMNA | |
| SCHEMBL4053067 | 0.86 | TRPV4 (0.46) | TRPV4CTSK | |
| SCHEMBL4049334 | 0.84 | TRPV4 (0.64) | TAS1R3TAS1R1TRPV4CTSSUTS2R | |
| SCHEMBL4051481 | 0.84 | TRPV4 (0.64) | TAS1R3TAS1R1TRPV4CTSSUTS2R | |
| SCHEMBL19856860 | 0.84 | TRPV4 (0.64) | TAS1R3TAS1R1TRPV4CTSSUTS2R | |
| SCHEMBL4049707 | 0.84 | TRPV4 (0.45) | TRPV4CTSSCTSL | |
| SCHEMBL4054443 | 0.84 | TRPV4 (0.46) | TAS1R3TAS1R1TRPV4CTSSUTS2R | |
| SCHEMBL4051572 | 0.84 | TRPV4 (0.64) | TAS1R3TAS1R1TRPV4CTSSUTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | claimed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |