Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 2/20 | 0.39 |
| ▸ | BCAT1 | P54687 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | CYP51A1 | Q16850 | 5/20 | 0.37 |
| ▸ | LGALS8 | O00214 | 3/20 | 0.37 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.37 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057673 | 0.94 | PYGL (0.39) | PYGLBCAT1DRD2CYP51A1DRD3 | |
| SCHEMBL4052196 | 0.90 | DRD4 (0.38) | PYGLDRD2CYP51A1DRD3EGFR | |
| SCHEMBL4051527 | 0.90 | DRD3 (0.39) | PYGLBCAT1DRD2CYP51A1LGALS8 | |
| SCHEMBL4056496 | 0.89 | TAS1R3 (0.46) | PYGLCYP51A1DRD3 | |
| SCHEMBL4051117 | 0.88 | ALOX15 (0.42) | PYGLBCAT1CYP51A1LGALS8ALOX15 | |
| SCHEMBL4050168 | 0.87 | DRD2 (0.36) | PYGLDRD2CYP51A1DRD3 | |
| SCHEMBL4049330 | 0.87 | PYGL (0.38) | PYGLDRD2CYP51A1DRD3ALOX15 | |
| SCHEMBL4050835 | 0.86 | DRD2 (0.39) | PYGLDRD2CYP51A1 | |
| SCHEMBL4049377 | 0.86 | CYP51A1 (0.39) | PYGLDRD2CYP51A1DRD3 | |
| SCHEMBL4052843 | 0.85 | PYGL (0.41) | PYGLBCAT1CYP51A1LGALS8LGALS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | claimed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |