Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 11/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 11/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4053392 | 0.94 | CYSLTR1 (0.39) | CYSLTR2CYSLTR1ALOX5APFFAR1AKR1B1 | |
| SCHEMBL5335837 | 0.92 | CYSLTR1 (0.39) | CYSLTR2CYSLTR1ALOX5APFFAR1AKR1B1 | |
| SCHEMBL6571774 | 0.84 | ALOX5AP (0.35) | CYSLTR2CYSLTR1ALOX5AP | |
| SCHEMBL4060756 | 0.83 | PDE10A (0.41) | CYSLTR2CYSLTR1ALOX5APPDE10A | |
| SCHEMBL4052136 | 0.83 | CYSLTR2 (0.36) | CYSLTR2CYSLTR1ALOX5APFFAR1AKR1B1 | |
| SCHEMBL13765251 | 0.82 | CYSLTR1 (0.39) | CYSLTR2CYSLTR1 | |
| SCHEMBL4229150 | 0.82 | LTB4R (0.36) | CYSLTR2CYSLTR1ALOX5AP | |
| SCHEMBL4055033 | 0.81 | ALOX5AP (0.35) | CYSLTR2CYSLTR1ALOX5APFFAR1AKR1B1 | |
| SCHEMBL5331476 | 0.80 | TBXA2R (0.42) | — | |
| SCHEMBL4051700 | 0.79 | CYSLTR2 (0.38) | CYSLTR2CYSLTR1ALOX5APFFAR1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |