Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | METAP1 | P53582 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 3/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | LATS1 | O95835 | 3/20 | 0.36 |
| ▸ | LATS2 | Q9NRM7 | 2/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10965568 | 0.71 | METAP2 (0.41) | METAP2METAP1GSK3AGSK3B | |
| SCHEMBL4118075 | 0.70 | ALDH1A1 (0.69) | METAP2 | |
| SCHEMBL3423341 | 0.70 | CCNC (0.50) | METAP2CCNCCDK8LATS1LATS2 | |
| SCHEMBL10740734 | 0.69 | PDE5A (0.65) | METAP2METAP1ALOX5GSK3AGSK3B | |
| SCHEMBL10742556 | 0.69 | METAP2 (0.57) | METAP2METAP1GSK3B | |
| SCHEMBL10738710 | 0.69 | METAP2 (0.53) | METAP2METAP1 | |
| SCHEMBL10737707 | 0.69 | PDE5A (0.68) | METAP2METAP1GSK3AGSK3B | |
| SCHEMBL10742987 | 0.69 | METAP2 (0.53) | METAP2METAP1ALOX5 | |
| SCHEMBL10674903 | 0.68 | SLC9A1 (0.45) | CCNCCDK8MAPK13GCGRMAPK12 | |
| SCHEMBL30874481 | 0.68 | METAP2 (0.55) | METAP2METAP1NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009029592-A1 | HETEROBICYCLIC-SUBSTITUTED QUINOLONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | KALYPSYS, INC. (US) | 2009-03-05 | — | — | WO | disclosed |