Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 2/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057289 | 0.90 | NOS2 (0.32) | NOS2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29640534 | 0.79 | NOTCH1 (0.33) | CA1CA2NOS2PSEN1PSEN2 | |
| SCHEMBL22660114 | 0.75 | NOTCH1 (0.34) | NOS2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6065531 | 0.74 | — | — | |
| SCHEMBL24108958 | 0.73 | NOS2 (0.42) | NOS2NOS3NOS1 | |
| SCHEMBL1876375 | 0.73 | NOS2 (0.42) | NOS2NOS3NOS1 | |
| SCHEMBL1642298 | 0.73 | NOS2 (0.42) | NOS2NOS3NOS1 | |
| SCHEMBL5399204 | 0.73 | ODC1 (0.31) | — | |
| SCHEMBL25958554 | 0.73 | CA1 (0.42) | CA1CA2NOS2 | |
| SCHEMBL9562376 | 0.73 | CA2 (0.52) | CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007505063-A | — | — | 2007-03-08 | — | — | JP | claimed |
| EP-1711470-A1 | MALONAMIDE DERIVATIVES BLOCKING THE ACTIVTIY OF GAMMA-SECRETASE | F. HOFFMANN-LA ROCHE AG (CH) | 2006-10-18 | — | — | EP | claimed |
| WO-2005023772-A1 | MALONAMIDE DERIVATIVES BLOCKING THE ACTIVITY OF GAMA-SECRETASE | F. HOFFMANN-LA ROCHE AG (CH) | 2005-03-17 | — | — | WO | claimed |