Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | CASP7 | P55210 | 1/20 | 0.68 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | FADS1 | O60427 | 1/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | ARNT | P27540 | 1/20 | 0.51 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7167600 | 0.89 | TDP1 (0.79) | L3MBTL1TDP1MAPK1ALDH1A1CASP7 | |
| SCHEMBL8886340 | 0.88 | L3MBTL1 (0.61) | L3MBTL1TDP1MAPK1ALDH1A1CASP7 | |
| SCHEMBL26468007 | 0.87 | TDP1 (0.77) | L3MBTL1TDP1MAPK1ALDH1A1CASP7 | |
| SCHEMBL7168043 | 0.84 | TDP1 (0.72) | L3MBTL1TDP1MAPK1ALDH1A1CASP7 | |
| SCHEMBL247794 | 0.82 | L3MBTL1 (0.74) | L3MBTL1TDP1MAPK1ALDH1A1CASP7 | |
| SCHEMBL4717840 | 0.81 | ALDH1A1 (0.70) | L3MBTL1ALDH1A1EPAS1MAPTGAA | |
| SCHEMBL28887269 | 0.81 | L3MBTL1 (0.55) | L3MBTL1TDP1MAPK1ALDH1A1CASP7 | |
| SCHEMBL230292 | 0.81 | TDP1 (1.00) | L3MBTL1TDP1MAPK1ALDH1A1CASP7 | |
| SCHEMBL31333098 | 0.81 | TDP1 (1.00) | L3MBTL1TDP1MAPK1ALDH1A1CASP7 | |
| SCHEMBL4942171 | 0.81 | ALDH1A1 (0.68) | L3MBTL1TDP1MAPK1ALDH1A1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| US-20080161366-A1 | AMINOALKYL SUBSTITUTED ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-07-03 | — | — | US | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161366-A1 | AMINOALKYL SUBSTITUTED ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | SLC6A4, SLC6A2, SLC6A3 | L3MBTL1 4326/4885TDP1 367/4885MAPK1 1634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.