Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 11/20 | 0.58 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | GUSB | P08236 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4060508 | 0.86 | PTGES (0.45) | AURKAIKBKETBK1PDE10ASMPD3 | |
| SCHEMBL4062195 | 0.85 | MGAM (0.45) | AURKAIKBKETBK1PDE10AGUSB | |
| SCHEMBL4050957 | 0.84 | IKBKE (0.49) | AURKAKIF11IKBKETBK1PDE10A | |
| SCHEMBL4055195 | 0.84 | AURKA (0.60) | AURKAIKBKETBK1SMPD3 | |
| SCHEMBL4050442 | 0.84 | GUSB (0.46) | AURKAKIF11IKBKETBK1GUSB | |
| SCHEMBL4061980 | 0.83 | AURKA (0.42) | AURKAKIF11IKBKETBK1PDE10A | |
| SCHEMBL13608558 | 0.83 | AURKA (0.46) | AURKAPDE10ANOTUM | |
| SCHEMBL4060428 | 0.83 | AURKA (0.66) | AURKAKIF11IKBKETBK1GUSB | |
| SCHEMBL4054953 | 0.82 | FGFR1 (0.49) | AURKAIKBKETBK1SMPD3 | |
| SCHEMBL4059279 | 0.81 | TBK1 (0.50) | AURKAIKBKETBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-20050101647-A1 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-05-12 | — | — | US | disclosed |
| EP-1460067-A1 | BICYCLIC DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE | Takeda Chemical Industries, Ltd. (JP) | 2004-09-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101647-A1 | Bicyclic derivative, its production and use | ABL1, SRC, PTK2B | AURKA 247/4885KIF11 1936/4885IKBKE 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.