Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2454830 | 0.84 | ALDH1A1 (0.50) | RXFP1BRD4HSD17B3ALDH1A1KDM4E | |
| SCHEMBL5483956 | 0.82 | MAOB (0.56) | BRD4ALDH1A1KDM4EMAPK1MAPT | |
| SCHEMBL21379597 | 0.78 | HSD17B3 (0.46) | RXFP1BRD4HSD17B3ALDH1A1KDM4E | |
| SCHEMBL1147722 | 0.76 | HSD17B3 (0.51) | RXFP1HSD17B3ALDH1A1KDM4EHPGD | |
| SCHEMBL3063473 | 0.76 | HSD17B3 (0.44) | RXFP1BRD4HSD17B3ALDH1A1KDM4E | |
| SCHEMBL25190307 | 0.73 | HSD17B3 (0.42) | RXFP1BRD4HSD17B3ALDH1A1KDM4E | |
| SCHEMBL22011788 | 0.73 | PGAM1 (0.42) | RXFP1ALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL22010968 | 0.72 | PGAM1 (0.42) | — | |
| SCHEMBL22011226 | 0.71 | HMGCR (0.36) | RXFP1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL22010964 | 0.69 | KDM4E (0.37) | RXFP1ALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220409668-A1 | GENETICALLY MODIFIED HUMAN STEM CELL EXPRESSING A MUTANT HUMAN CYTOCHROME P450 2B6 PROTEIN AND USE THEREOF IN THE TREATMENT OF CANCER | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2022-12-29 | — | — | US | disclosed |
| WO-2021074162-A1 | GENETICALLY MODIFIED HUMAN STEM CELL EXPRESSING A MUTANT HUMAN CYTOCHROME P450 2B6 PROTEIN AND USE THEREOF IN THE TREATMENT OF CANCER | ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (FR) | 2021-04-22 | — | — | WO | disclosed |
| WO-2021074167-A1 | GENETICALLY MODIFIED HUMAN STEM CELL EXPRESSING A MUTANT HUMAN CYTOCHROME P450 2B6 PROTEIN AND USE THEREOF IN THE TREATMENT OF CANCER | ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (FR) | 2021-04-22 | — | — | WO | disclosed |
| EP-2705052-B1 | MUTANT CYTOCHROME P450 2B6 PROTEINS AND USES THEREOF | INST NAT DE LA SANTÉ ET DE LA RECH MÉDICALE (INSERM) (FR) | 2017-11-15 | — | — | EP | disclosed |
| US-9243231-B2 | Mutant cytochrome P450 2B6 proteins and uses thereof | INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) (FR) | 2016-01-26 | — | — | US | disclosed |
| US-20140127180-A1 | MUTANT CYTOCHROME P450 2B6 PROTEINS AND USES THEREOF | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2014-05-08 | — | — | US | disclosed |
| EP-2705052-A1 | MUTANT CYTOCHROME P450 2B6 PROTEINS AND USES THEREOF | Institut National de la Sante et de la Recherche Medicale (INSERM) (FR) | 2014-03-12 | — | — | EP | disclosed |
| WO-2012150326-A1 | MUTANT CYTOCHROME P450 2B6 PROTEINS AND USES THEREOF | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2012-11-08 | — | — | WO | disclosed |
| WO-2009106882-A1 | CYTOCHROME B5 KNOCKOUT ANIMAL MODELS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-09-03 | — | — | WO | disclosed |