Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3751257 | 1.00 | KEAP1 (0.33) | KEAP1NFE2L2HCAR2ALDH1A1 | |
| SCHEMBL5874735 | 0.97 | ALDH1A1 (0.35) | KEAP1NFE2L2HCAR2ALDH1A1 | |
| SCHEMBL5875212 | 0.97 | ALDH1A1 (0.35) | KEAP1NFE2L2HCAR2ALDH1A1 | |
| SCHEMBL1934761 | 0.95 | KEAP1 (0.33) | KEAP1NFE2L2HCAR2 | |
| SCHEMBL10992799 | 0.91 | HCAR2 (0.43) | HCAR2ALDH1A1 | |
| SCHEMBL3632775 | 0.91 | HCAR2 (0.43) | HCAR2ALDH1A1 | |
| SCHEMBL10859674 | 0.89 | HCAR2 (0.41) | HCAR2 | |
| SCHEMBL10859682 | 0.89 | HCAR2 (0.41) | HCAR2 | |
| SCHEMBL17695729 | 0.87 | NFE2L2 (0.52) | KEAP1NFE2L2HCAR2ALDH1A1 | |
| SCHEMBL20240604 | 0.86 | GSTP1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009094457-A2 | SUBSTITUTED BENZHYDRYLETHERS | AUSPEX PHARMACEUTICALS (US) | 2009-07-30 | — | — | WO | disclosed |
| CN-101426778-A | N-substituted-azacyclylamines as histamine-3 antagonists | WYETH CORP (US) | 2009-05-06 | — | — | CN | disclosed |
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | disclosed |
| US-4698430-A | ANTIDEPRESSANT | A. H. ROBINS COMPANY, INC. (US) | 1987-10-06 | — | — | US | disclosed |