Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | GABRP | O00591 | 5/20 | 0.44 |
| ▸ | GABRD | O14764 | 5/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 5/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.44 |
| ▸ | GABRE | P78334 | 5/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.44 |
| ▸ | GABRG1 | Q8N1C3 | 5/20 | 0.44 |
| ▸ | GABRG3 | Q99928 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3112919 | 0.86 | ALDH1A1 (0.48) | MAPTNPC1ALDH1A1LMNAPOLB | |
| SCHEMBL1336270 | 0.84 | MAPK1 (0.45) | MAPTALDH1A1LMNAPOLBGABRP | |
| SCHEMBL19231419 | 0.81 | GABRA1 (0.47) | MAPTNPC1ALDH1A1LMNAPOLB | |
| SCHEMBL41011 | 0.81 | GABRA1 (0.51) | MAPTNPC1ALDH1A1LMNAPOLB | |
| SCHEMBL1338068 | 0.77 | LMNA (0.47) | MAPTALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL23350063 | 0.77 | GABRA1 (0.48) | MAPTNPC1ALDH1A1LMNAPOLB | |
| SCHEMBL30100094 | 0.77 | GABRA1 (0.48) | MAPTNPC1ALDH1A1LMNAPOLB | |
| SCHEMBL4799762 | 0.76 | ALDH1A1 (0.41) | MAPTNPC1ALDH1A1LMNAPOLB | |
| SCHEMBL3110544 | 0.76 | GABRA1 (0.50) | MAPTNPC1ALDH1A1LMNAPOLB | |
| Water SCHEMBL3559493 | 0.76 | LMNA (0.46) | MAPTALDH1A1LMNAPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10138245-B2 | Fused triazole derivatives as phosphodiesterase 10A inhibitors | CELON PHARMA S.A. (PL) | 2018-11-27 | — | — | US | disclosed |
| EP-3145930-B1 | FUSED TRIAZOLE DERIVATIVES AS PHOSPHODIESTERASE 10A INHIBITORS | Celon Pharma Sa (PL) | 2018-07-04 | — | — | EP | disclosed |
| US-20170114064-A1 | FUSED TRIAZOLE DERIVATIVES AS PHOSPHODIESTERASE 10A INHIBITORS | CELON PHARMA S.A. (PL) | 2017-04-27 | — | — | US | disclosed |
| EP-3145930-A1 | FUSED TRIAZOLE DERIVATIVES AS PHOSPHODIESTERASE 10A INHIBITORS | CELON PHARMA S.A. (PL) | 2017-03-29 | — | — | EP | disclosed |
| US-20160296507-A1 | IMIDAZOPYRIDINE, IMIDAZOPYRIMIDINE AND IMIDAZOPYRAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | UNIVERSITE DE MONTREAL (CA) | 2016-10-13 | — | — | US | disclosed |
| US-20160296507-A1 | IMIDAZOPYRIDINE, IMIDAZOPYRIMIDINE AND IMIDAZOPYRAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | UNIVERSITE DE MONTREAL (CA) | 2016-10-13 | — | — | US | disclosed |
| WO-2015177688-A1 | FUSED TRIAZOLE DERIVATIVES AS PHOSPHODIESTERASE 10A INHIBITORS | CELON PHARMA S.A. (PL) | 2015-11-26 | — | — | WO | disclosed |
| US-20130165426-A1 | IMIDAZOPYRIDINE, IMIDAZOPYRIMIDINE AND IMIDAZOPYRAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | Université de Montréal (CA) | 2013-06-27 | — | — | US | disclosed |
| US-20130165426-A1 | IMIDAZOPYRIDINE, IMIDAZOPYRIMIDINE AND IMIDAZOPYRAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | Université de Montréal (CA) | 2013-06-27 | — | — | US | disclosed |
| WO-2012003576-A1 | IMIDAZOPYRIDINE, IMIDAZOPYRIMIDINE AND IMIDAZOPYRAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | Université de Montréal (CA) | 2012-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10138245-B2 | Fused triazole derivatives as phosphodiesterase 10A inhibitors | PDE3B, PDE3A, PDE5A | MAPT 1572/4885NPC1 3274/4885ALDH1A1 1427/4885 |
| US-20130165426-A1 | IMIDAZOPYRIDINE, IMIDAZOPYRIMIDINE AND IMIDAZOPYRAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | MC4R, MC5R, MC1R | MAPT 3453/4885NPC1 3129/4885ALDH1A1 2932/4885 |
| US-20160296507-A1 | IMIDAZOPYRIDINE, IMIDAZOPYRIMIDINE AND IMIDAZOPYRAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | MC4R, MC5R, MC1R | MAPT 3371/4885NPC1 3266/4885ALDH1A1 2935/4885 |
| US-20170114064-A1 | FUSED TRIAZOLE DERIVATIVES AS PHOSPHODIESTERASE 10A INHIBITORS | PDE3B, PDE3A, PDE5A | MAPT 1572/4885NPC1 3274/4885ALDH1A1 1427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.